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Image Search Results
Journal: eNeuro
Article Title: Dopamine and Calcium Dynamics in the Nucleus Accumbens Core during Food Seeking
doi: 10.1523/ENEURO.0380-25.2026
Figure Lengend Snippet: Behavior and virus expression during food self-administration training, extinction training, and reinstatement testing. A , Timeline for experiment. Behavioral and fiber photometry data are reported for adult Long–Evans rats (6 male, 5 female). B , Representative image of virus coexpression: left, AAV9-syn-jGCaMP8s-WPRE; middle, AAV2/9-hsyn-rDA3m; and right, overlap of viral expression. The cannula track appears as an oblong shape terminating to the right of the anterior commissure. C , Fiber-optic cannula placement for rats. The dot signifies the end of the cannula (females, pink; males, blue). Placement was determined after immunohistochemistry for GFP and mApple to confirm virus expression at the end of the cannula. Sections adapted from Paxinos & Watson 7th edition. D , Food self-administration sessions (SA1–4), extinction sessions (Ext1–6), and reinstatement tests. Left, Active lever presses for all rats ( n = 11) across all sessions for all behavioral phases. Right, Inactive lever presses for the same sessions. E , Data from D graphed to show direct comparison of SA4, Ext6, Cue-primed reinstatement, and Pellet + Cue-primed reinstatement (*** p < 0.0001, * p < 0.05). Error bars indicate mean (±SEM) for each session while dots represent individual rats. AP, anterior posterior; ac, anterior commissure; NAcc, nucleus accumbens core. Full statistical output for experiments shown in this figure is presented in . Additional analyses related to data in this figure are presented in Extended Data .
Article Snippet: They were connected to a
Techniques: Virus, Expressing, Immunohistochemistry, Comparison
Journal: Frontiers in Neuroengineering
Article Title: Real-time in vivo optogenetic neuromodulation and multielectrode electrophysiologic recording with NeuroRighter
doi: 10.3389/fneng.2014.00040
Figure Lengend Snippet: NeuroRighter software and hardware for calibration, optical stimulation, and recording. NeuroRighter’s main application window enables real-time isolation of single units (A) and local field potentials (LFP; B ) from multielectrode arrays, with real-time visualization of the electrophysiologic response to optical stimulus ( B , magenta arrow). (C) A comparison between the mean (dot) and SD (error bars) normalized output of a 473 nm blue DPSS Laser (Shanghai Dream Laser; red) and 465 nm blue LED (Plexon, Inc.) output (black). Note the high variance associated with the laser output as compared to the LED (present for the LED but smaller than the data point marker), and the non-linear nature of the laser output. (D) Plexon LED Driver, 465 nm blue LED module, and 200 μm 0.67 NA armored patch fiber cable. (E) Custom-made optical ferrules utilizing 200 μm diameter 0.37 NA fiber optic. (F) 3D-printed Intensity Chamber design (top) and fabricated with accompanying photodiode (bottom). Custom-designed and fabricated ferrules (E) plug into the chamber ( F , bottom right) which overlays the S121C detector ( F , bottom left). (G) Labview-based program for Automated Ferrule Intensity Calibration (C) . (H) A 3D-printed implantation post has multiple modules to enable ferrule implantation alone ( H , bottom right) or coupled to an array (H , top right, J) . (I) TDT 16-channel MEA, which was implanted in the dorsal hippocampus targeting CA1 and CA3 simultaneously. (J) A H-style NeuroNexus 16 channel shank array was manually glued to a calibrated ferrule (K) , enabling simultaneous stimulation, and recording from the same target site.
Article Snippet: To stimulate awake and behaving animals, calibrated ferrules were connected via
Techniques: Software, Isolation, Marker